Define a model with lag time

[AlejandraSchiavo]

Hi,
Can you help me to define a delayed first order absorption model in PopED?
Thank you

Alejandra

[andrewhooker]

Hi Alejandra, Sure. Were you thinking a lag-time delay or transit-compartments? Best regards, Andy Andrew Hooker, Ph.D. Professor of Pharmacometrics Dept. of Pharmacy Uppsala University Box 580, 751 23, Uppsala, Sweden Phone: +46 18 471 4355 https://katalog.uu.se/profile/?id=N4-631  <https://katalog.uu.se/profile/?id=N4-631> <http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/>

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On 13 Jun 2023, at 14:51, AlejandraSchiavo ***@***.***> wrote: Hi, Can you help me to define a delayed first order absorption model in PopED? Thank you Alejandra — Reply to this email directly, view it on GitHub <#69>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/ABJOMZGFATKH5I3FN7AQJS3XLBO35ANCNFSM6AAAAAAZE2D76M>. You are receiving this because you are subscribed to this thread.

[AlejandraSchiavo]

Hi Andrew,
I need a lag-time delay to desrcibe an oral delayed-release formulation.
Thank you,

[AlejandraSchiavo]

Maybe it helps: I am working on a model with differential equations. I suppose that the lag time should be defined in the "ff" function, but I can't find an example that indicates where to define it.
Thanks,
Alejandra

[SayakaMtmt]

Hi
I also would like to know how to define lag-time or Duration of zero-order.
Dear @andrewhooker , if you could give any advise, I would be happy!

Thanks,
Sayaka

[dconrado-eq]

@andrewhooker, @AlejandraSchiavo, @SayakaMtmt - I have the same question on adding a Tlag to a differential equation (not closed form) model. Could you send an example please?

[JoanaXu]

Hi @andrewhooker, @AlejandraSchiavo, @SayakaMtmt,@dconrado-eq,d I have the same question on adding a lag-time delay with ODE, is there a solution?

[mattfidler]

You could use nlmixr2's PopED functionality included in babelmixr2 which definitely allows a lag-time with ODEs:

lag(cmt) <- lagCmt

For examples on how PopED and nlmixr2 work together see:

https://nlmixr2.github.io/babelmixr2/articles/PopED.html

And

https://github.com/nlmixr2/babelmixr2/tree/main/inst/poped

If you are using Windows, the parallel support isn't yet integrated (#79), but you could use that branch.

remotes::install_github("mattfidler/PopED", ref="babelmixr2-win")

[mattfidler]

If you want to add a transit compartment, you can use nlmixr2lib with an oral model

https://nlmixr2.github.io/nlmixr2lib/reference/addTransit.html