diff --git a/mite_data/data/89258932-5f25-11f1-bc58-c13514790332.json b/mite_data/data/89258932-5f25-11f1-bc58-c13514790332.json new file mode 100644 index 00000000..5a9f5d95 --- /dev/null +++ b/mite_data/data/89258932-5f25-11f1-bc58-c13514790332.json @@ -0,0 +1,57 @@ +{ + "accession": "MITE9999999", + "status": "pending", + "comment": "Associated MIBiG BGC BGC0001353 was retired", + "changelog": [ + { + "version": "1", + "date": "2026-06-03", + "contributors": [ + "0009-0000-8651-1669" + ], + "reviewers": [ + "BBBBBBBBBBBBBBBBBBBBBBBB" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "ChlH", + "description": "Flavin-dependent halogenase", + "references": [ + "doi:10.1021/acs.jnatprod.4c01199" + ], + "databaseIds": { + "uniprot": "A0A1H0TT13", + "genpept": "SDP57011.1" + } + }, + "reactions": [ + { + "tailoring": [ + "Halogenation" + ], + "description": "(iterative) di-, mono-, nonchlorination of L-Tryptophan aminoacidsgroups in the chlorolassin pathway prior to lasso formation", + "reactionSMARTS": "[NH2:1][C@H:2]([CH:13]=[O:14])[CH2:3][c:4]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:7]2[nH:6][cH:5]1>>[NH2:1][C@H:2]([CH:13]=[O:14])[CH2:3][c:4]1[c:8]2[cH:9][c:10](Cl)[cH:11][cH:12][c:7]2[nH:6][cH:5]1", + "reactions": [ + { + "substrate": "N[C@H](C=O)Cc1c[nH]c2ccccc12", + "products": [ + "N[C@H](C=O)Cc1c[nH]c2ccc(Cl)cc12" + ], + "isIntermediate": false, + "description": "Halogenation of free-floating tryptophan aminoacidgroups as prescurser in the chlorolassin pathway " + } + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression", + "In vitro assay" + ], + "references": [ + "doi:10.1021/acs.jnatprod.4c01199" + ] + } + } + ] +} \ No newline at end of file