From 9098bc79550d102d67c585c789228fbe58898d18 Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Fri, 12 Jun 2026 19:10:17 +0200
Subject: [PATCH 1/2] Add submission UUID file

---
 .../36265c26-6681-11f1-8c13-d1bbc094d4fb.json | 44 +++++++++++++++++++
 1 file changed, 44 insertions(+)
 create mode 100644 mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json

diff --git a/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json b/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json
new file mode 100644
index 00000000..f0eb7da4
--- /dev/null
+++ b/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json
@@ -0,0 +1,44 @@
+{
+    "accession": "MITE9999999",
+    "status": "pending",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-06-12",
+            "contributors": [
+                "0000-0002-3947-4444"
+            ],
+            "reviewers": [
+                "BBBBBBBBBBBBBBBBBBBBBBBB"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "CczI",
+        "databaseIds": {
+            "uniprot": "",
+            "genpept": "YAS72841.1"
+        },
+        "references": [
+            "doi:"
+        ]
+    },
+    "reactions": [
+        {
+            "evidence": {
+                "evidenceCode": [],
+                "references": [
+                    "doi:"
+                ]
+            },
+            "reactions": [
+                {
+                    "products": [
+                        ""
+                    ]
+                }
+            ]
+        }
+    ]
+}
\ No newline at end of file

From ba893a2290f981da602289754f2ae27000b78996 Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Fri, 12 Jun 2026 19:43:41 +0200
Subject: [PATCH 2/2] Update submission

---
 .../36265c26-6681-11f1-8c13-d1bbc094d4fb.json | 49 +++++++++++++------
 1 file changed, 35 insertions(+), 14 deletions(-)

diff --git a/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json b/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json
index f0eb7da4..e1a2904c 100644
--- a/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json
+++ b/mite_data/data/36265c26-6681-11f1-8c13-d1bbc094d4fb.json
@@ -1,6 +1,7 @@
 {
     "accession": "MITE9999999",
     "status": "pending",
+    "comment": "Methylation of C-hydroxycarbazole and derivatives.",
     "changelog": [
         {
             "version": "1",
@@ -11,34 +12,54 @@
             "reviewers": [
                 "BBBBBBBBBBBBBBBBBBBBBBBB"
             ],
-            "comment": "New entry."
+            "comment": "Add new entry for CczI"
         }
     ],
     "enzyme": {
         "name": "CczI",
+        "description": "O-methyltransferase",
+        "references": [
+            "doi:10.1021/acs.orglett.5c04621"
+        ],
         "databaseIds": {
-            "uniprot": "",
+            "uniprot": "A0A367F2Z6",
             "genpept": "YAS72841.1"
         },
-        "references": [
-            "doi:"
-        ]
+        "cofactors": {
+            "organic": [
+                "SAM"
+            ]
+        }
     },
     "reactions": [
         {
-            "evidence": {
-                "evidenceCode": [],
-                "references": [
-                    "doi:"
-                ]
-            },
+            "tailoring": [
+                "Biaryl bond formation",
+                "Methylation",
+                "Reduction"
+            ],
+            "description": "Methylation of C-hydroxycarbazole",
+            "reactionSMARTS": "[#6:1]12:[#7:13]:[#6:8]3:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:3:[#6:6]:1:[#6:5]:[#6:4](-[#8:14]):[#6:3]:[#6:2]:2>>[#6:1]12:[#7:13]:[#6:8]3:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:3:[#6:6]:1:[#6:5]:[#6:4](-[#8:14]-[#6]):[#6:3]:[#6:2]:2",
             "reactions": [
                 {
+                    "substrate": "Oc1ccc2[nH]c3ccccc3c2c1Cl",
                     "products": [
-                        ""
-                    ]
+                        "COc1ccc2[nH]c3ccccc3c2c1Cl"
+                    ],
+                    "isIntermediate": true,
+                    "description": "O-methylation of 3-hydroxy-4-chlorocarbazole"
                 }
-            ]
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Heterologous expression",
+                    "In vitro assay",
+                    "Knock-out studies"
+                ],
+                "references": [
+                    "doi:10.1021/acs.orglett.5c04621"
+                ]
+            }
         }
     ]
 }
\ No newline at end of file