From f9b5116e9b1162e2ddfcef298e7a5ebbde5517f5 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Tue, 16 Jun 2026 19:10:02 +0200 Subject: [PATCH 1/2] Add submission UUID file --- .../91cb13e2-69a5-11f1-822f-9b3014917364.json | 44 +++++++++++++++++++ 1 file changed, 44 insertions(+) create mode 100644 mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json diff --git a/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json b/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json new file mode 100644 index 00000000..3e9dc8dc --- /dev/null +++ b/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json @@ -0,0 +1,44 @@ +{ + "accession": "MITE9999999", + "status": "pending", + "changelog": [ + { + "version": "1", + "date": "2026-06-16", + "contributors": [ + "0009-0008-8086-5325" + ], + "reviewers": [ + "BBBBBBBBBBBBBBBBBBBBBBBB" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "GutD2774", + "databaseIds": { + "uniprot": "UPI00068B4E68", + "genpept": "" + }, + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "evidence": { + "evidenceCode": [], + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "products": [ + "" + ] + } + ] + } + ] +} \ No newline at end of file From b10675772728223381e741d77113bdd5768be282 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Tue, 16 Jun 2026 21:27:48 +0200 Subject: [PATCH 2/2] Update submission --- .../91cb13e2-69a5-11f1-822f-9b3014917364.json | 67 ++++++++++++++++--- 1 file changed, 57 insertions(+), 10 deletions(-) diff --git a/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json b/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json index 3e9dc8dc..bdcf01f4 100644 --- a/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json +++ b/mite_data/data/91cb13e2-69a5-11f1-822f-9b3014917364.json @@ -1,6 +1,7 @@ { "accession": "MITE9999999", "status": "pending", + "comment": "GutD2774 catalyzes the transfer of hypoxanthine and guanine to the indole ring of cyclo-l-Trp-l-Trp", "changelog": [ { "version": "1", @@ -16,29 +17,75 @@ ], "enzyme": { "name": "GutD2774", + "description": "Cytochrome P450", + "references": [ + "doi:10.1021/acs.orglett.9b03491" + ], "databaseIds": { "uniprot": "UPI00068B4E68", - "genpept": "" + "mibig": "BGC0003082" }, - "references": [ - "doi:" - ] + "cofactors": { + "organic": [ + "Heme" + ], + "inorganic": [ + "Fe" + ] + } }, "reactions": [ { + "tailoring": [ + "Other" + ], + "description": "GutD2774 use the substrate cWW and attach hypoxanthine via its N1 \u0301 to C2 (Guanitrypmycin C3-3) and C2 \u0301 to C3 (Guanitrypmycin C3-4) of the indole", + "reactionSMARTS": "[#8]=[#6:2]1-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:11]-[#6:10]-[#6:9]-[#6:8]-[#6:7]-2-3)-[#7:4]-[#6:27](=[#8:28])-[#6:16](-[#6:17]-[#6:18]2-[#6:19]-[#7:20]-[#6:21]3-[#6:22]-2-[#6:23]-[#6:24]-[#6:25]-[#6:26]-3)-[#7:15]-1.[#7]1-[#6]-[#7]-[#6]2-[#6](=[#8])-[#7]-[#6]-[#7]-[#6]-1-2>>[#8:28]=[#6:27]1-[#6:16]2-[#7:15](-[#6:19]3-[#6:18](-[#6:17]-2)(-[#6]2-[#7]-[#6]4-[#6](-[#7]-[#6]-[#7]-4)-[#6](=[#8])-[#7]-2)-[#6:22]2-[#6:21](-[#6:26]-[#6:25]-[#6:24]-[#6:23]-2)-[#7:20]-3)-[#6:2](=[#8])-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:7]-2-[#6:8]-[#6:9]-[#6:10]-[#6:11]-3)-[#7:4]-1.[#8]=[#6:27]1-[#6:16](-[#6:17]-[#6:18]2-[#6:19](-[#7]3-[#6](=[#8])-[#6]4-[#7]-[#6]-[#7]-[#6]-4-[#7]-[#6]-3)-[#7:20]-[#6:21]3-[#6:26]-[#6:25]-[#6:24]-[#6:23]-[#6:22]-2-3)-[#7:15]-[#6:2](=[#8:1])-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:7]-2-[#6:8]-[#6:9]-[#6:10]-[#6:11]-3)-[#7:4]-1", + "reactions": [ + { + "substrate": "O=C1NC(CC2CNC3CCCCC23)C(=O)NC1CC1CNC2CCCCC12.O=C1NCNC2NCNC12", + "products": [ + "O=C1NC(C23CC4C(=O)NC(CC5CNC6CCCCC56)C(=O)N4C2NC2CCCCC23)NC2NCNC12", + "O=C1NC(CC2C3CCCCC3NC2N2CNC3NCNC3C2=O)C(=O)NC1CC1CNC2CCCCC12" + ], + "isIntermediate": false + } + ], "evidence": { - "evidenceCode": [], + "evidenceCode": [ + "Heterologous expression", + "In vitro assay" + ], "references": [ - "doi:" + "doi:10.1021/acs.orglett.9b03491" ] - }, + } + }, + { + "tailoring": [ + "Other" + ], + "description": "GutD2774 also uses guanine as a substrate, resulting in the formation of the minor side products guanitrypmycin C3-1 (C8' to N1 of indole) and guanitrypmycin C3-2 (C8' to C3 of indole) ", + "reactionSMARTS": "[#8:1]=[#6:2]1-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:11]-[#6:10]-[#6:9]-[#6:8]-[#6:7]-2-3)-[#7:4]-[#6:27](=[#8:28])-[#6:16](-[#6:17]-[#6:18]2-[#6:19]-[#7:20]-[#6:21]3-[#6:22]-2-[#6:23]-[#6:24]-[#6:25]-[#6:26]-3)-[#7:15]-1.[#7]1-[#6]-[#7]-[#6]2-[#6](=[#8])-[#7]-[#6](-[#7])-[#7]-[#6]-1-2>>[#8:28]=[#6:27]1-[#6:16](-[#6:17]-[#6:18]2-[#6:19]-[#7:20](-[#6]3-[#7]-[#6]4-[#6](-[#7]-[#6](-[#7]-[#6]-4=[#8])-[#7])-[#7]-3)-[#6:21]3-[#6:26]-[#6:25]-[#6:24]-[#6:23]-[#6:22]-2-3)-[#7:15]-[#6:2](=[#8:1])-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:7]-2-[#6:8]-[#6:9]-[#6:10]-[#6:11]-3)-[#7:4]-1.[#8:28]=[#6:27]1-[#6:16]2-[#7:15](-[#6:19]3-[#6:18](-[#6:17]-2)(-[#6]2-[#7]-[#6]4-[#6](-[#6](-[#7]-[#6](-[#7]-4)-[#7])=[#8])-[#7]-2)-[#6:22]2-[#6:21](-[#6:26]-[#6:25]-[#6:24]-[#6:23]-2)-[#7:20]-3)-[#6:2](=[#8:1])-[#6:3](-[#6:14]-[#6:6]2-[#6:5]-[#7:13]-[#6:12]3-[#6:7]-2-[#6:8]-[#6:9]-[#6:10]-[#6:11]-3)-[#7:4]-1", "reactions": [ { + "substrate": "NC1NC(=O)C2NCNC2N1.O=C1NC(CC2CNC3CCCCC23)C(=O)NC1CC1CNC2CCCCC12", "products": [ - "" - ] + "NC1NC(=O)C2NC(N3CC(CC4NC(=O)C(CC5CNC6CCCCC56)NC4=O)C4CCCCC43)NC2N1", + "NC1NC(=O)C2NC(C34CC5C(=O)NC(CC6CNC7CCCCC67)C(=O)N5C3NC3CCCCC34)NC2N1" + ], + "isIntermediate": false } - ] + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression", + "In vitro assay" + ], + "references": [ + "doi:10.1021/acs.orglett.9b03491" + ] + } } ] } \ No newline at end of file