Contributor submission ChlH

mite_data/data/89258932-5f25-11f1-bc58-c13514790332.json

@@ -0,0 +1,57 @@
+{
+    "accession": "MITE9999999",
+    "status": "pending",
+    "comment": "Associated MIBiG BGC BGC0001353 was retired",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-06-03",
+            "contributors": [
+                "0009-0000-8651-1669"
+            ],
+            "reviewers": [
+                "BBBBBBBBBBBBBBBBBBBBBBBB"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "ChlH",
+        "description": "Flavin-dependent halogenase",
+        "references": [
+            "doi:10.1021/acs.jnatprod.4c01199"
+        ],
+        "databaseIds": {
+            "uniprot": "A0A1H0TT13",
+            "genpept": "SDP57011.1"
+        }
+    },
+    "reactions": [
+        {
+            "tailoring": [
+                "Halogenation"
+            ],
+            "description": "(iterative) di-, mono-, nonchlorination of L-Tryptophan aminoacidsgroups in the chlorolassin pathway prior to lasso formation",
+            "reactionSMARTS": "[NH2:1][C@H:2]([CH:13]=[O:14])[CH2:3][c:4]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:7]2[nH:6][cH:5]1>>[NH2:1][C@H:2]([CH:13]=[O:14])[CH2:3][c:4]1[c:8]2[cH:9][c:10](Cl)[cH:11][cH:12][c:7]2[nH:6][cH:5]1",
+            "reactions": [
+                {
+                    "substrate": "N[C@H](C=O)Cc1c[nH]c2ccccc12",
+                    "products": [
+                        "N[C@H](C=O)Cc1c[nH]c2ccc(Cl)cc12"
+                    ],
+                    "isIntermediate": false,
+                    "description": "Halogenation of free-floating tryptophan aminoacidgroups as prescurser in the chlorolassin pathway "
+                }
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Heterologous expression",
+                    "In vitro assay"
+                ],
+                "references": [
+                    "doi:10.1021/acs.jnatprod.4c01199"
+                ]
+            }
+        }
+    ]
+}